Pyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart
Wang Y, Guo D, Zhu J, Yang X, Wu C, Geng J, Liang Q, Sun N, Niu X, Liu Y, Guo Y, Chang P, Li Y, Hu L. Pyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart. Nat Commun. 2026 Mar 14;17(1):3929.
小鼠
心血管疾病
2026
ARMH4 accelerates aging by maintaining a positive-feedback growth signaling circuit.
Fang Y, Wang B, Guo Q, Lv J, Li J, Wang J, Guo N, Bai Y, Xu A, Ma X, Tan H, Li H, Wang Z. ARMH4 accelerates aging by maintaining a positive-feedback growth signaling circuit. Nat Commun. 2025 Dec 14;17(1):812.
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心血管疾病
2025
NAT10-Mediated ac4C-Modification Exacerbates Ferroptosis by Stabilizing HMOX1 in Deep Vein Thrombosis
Zhang Y, Zhang Z, Liu X, Chu C, Yu X, Han Q, Li W, Zhang T, Zu H, Fan N, Wei R, Shi F, Li F, Xu F, Wang B, Li X. NAT10-Mediated ac4C-Modification Exacerbates Ferroptosis by Stabilizing HMOX1 in Deep Vein Thrombosis. Arterioscler Thromb Vasc Biol. 2026 Feb;46(2):e323986.
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血管
2025
Engeletin alleviates doxorubicin-induced cardiotoxicity via the AMPK pathway in mice
Chen X, Zhong X, Luo D, Huang Q, Tang P, Ye L, Lei Y, Huang R. Engeletin alleviates doxorubicin-induced cardiotoxicity via the AMPK pathway in mice. Front Pharmacol. 2026 Feb 26;17:1741741.
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2026
Mongolian medicine Wulanwendusu-11 alleviates myocardial ischemia-reperfusion injury by modulating the intestinal microbiota and associated metabolic pathways.
Wuyunsiqin, Bai T, Yang D, Hashentuya, Namila, Jin C, Tana, Zhao P, Wang M, Menggenduxi. Mongolian medicine Wulanwendusu-11 alleviates myocardial ischemia-reperfusion injury by modulating the intestinal microbiota and associated metabolic pathways. Front Microbiol. 2026 Jan 9;16:1693472.
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2026
SLC1A5 prevents aortic aneurysm and dissection by glutaminolytic-epigenetic orchestration of vascular smooth muscle cell homeostasis
Yang P, Gao Z, Ye W, Zhou C, Zheng Z, Su M, He Y, Li Z, Pelisek J, He K, Xu S, Wang J, Liu Z. SLC1A5 prevents aortic aneurysm and dissection by glutaminolytic-epigenetic orchestration of vascular smooth muscle cell homeostasis. Nat Commun. 2026 Apr 15.
小鼠
心血管疾病
2026
